¹Department of Pharmaceutical Microbiology, Institute of Graduate Studies in Health Sciences, Istanbul University 34116, Beyazıt/Istanbul, Türkiye
²Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Marmara University, Başıbüyük/Istanbul, Türkiye
³Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazıt/Istanbul, Türkiye DOI : 10.29228/jrp.714 Because the emergence of antimicrobial resistance worldwide and alternative treatment strategies against Staphylococcus aureus infections are still being sought, we investigated a new bacteriophage with a lytic effect against S. aureus strains in this study. Then, we isolated potentially therapeutic lytic S. aureus phage from seawater and determined the biological characterization and in vitro lytic effect against various clinical bacterial strains. As a result, our study provides evidence of phage application for S. aureus strains, combination studies with conventional antibiotics as an alternative treatment option in clinical. Keywords : Phage-antibiotic combination; Staphylococcus aureus; bacteriophage; biofilm