¹Department of Biology, Faculty of Information, Technology and Science, Universitas Hindu Indonesia, Denpasar city, 80236, Indonesia
²Department of Tropical Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya city, 60132, Indonesia
³Associate Epidemiologist, Indonesian Society of Epidemiologists, Daerah Khusus Ibukota Jakarta 10560, Indonesia
⁴Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya city, 60132, Indonesia
⁵Delima Husada Gresik Health Analyst Academy, Gresik District, 61111, Indonesia
⁶Department of Medical Education, Faculty of Medicine and Health, Institut Teknologi Sepuluh Nopember, Surabaya city, 60111, Indonesia
⁷Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya city, 60132, Indonesia
⁸Master Program of Tropical Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya city, 60132, Indonesia DOI : 10.29228/jrp.700 Terna plants are used by Indonesians as raw materials for herbal and traditional medicine, including Phyllantus niruri L. and Phyllantus urinaria L. Therefore, this study aimed to explore, analyze and compile the activities and potential of Phyllantus niruri L. and Phyllantus urinaria L. as agents of hepatitis B virus (HBV) inhibitors using a narrative review approach. It was conducted based on the Scale for the Assessment of Narrative Review Articles (SANRA) by establishing inclusion and exclusion criteria. The study selected and reviewed 15 out of 38 articles. The Phyllantus genus is a group of seasonal herbs containing bioactive compounds and activity as HBV Inhibitors. In this study, 23 compounds were identified in the two species, including Nirtetralin, Phyllanthin, Niranthin, Hinokinin, Ellagic acid, Ethanol, Phyllanthosterol, Ethyl brevifolincarboxylate, Tenofovir, Quercetin, Quercitrin, Astragalin, Repanducinic acid, Corilagin, Gallic acid, Aloe-emodin-8-O-β-D-glucopyranoside, Catechin, D-glucopyranoside, Ethyl gallate, Protocatequatic acid, Chebulanin, Albibrissinoside B, and (-)-Epicatechin. Meanwhile, the activity in inhibiting cells infected with HBV was reported in vitro, in vivo, ex vivo, and in silico. The mechanism of bioactive compounds as HBV inhibitors focuses on suppression, blocking, and inhibiting the synthesis, secretion, and expression of HBsAg, HBcAg, and HbeAg in test media. The results showed that Meniran red and green bioactive compounds have the potential to be developed as raw materials as herbal medicine with promising prospects as commercial drug candidates. Keywords : Anti hepatitis B Virus; meniran; medicinal plants; therapeutic agents; traditional medicine