Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal
1993 , Vol 9 , Issue 1
The effects of N-nitrosomorpholine on rat kidney lactate dehydrogenase and alkaline phosphatase activities
The in vivo effects of N-Nitrosomorpholine(NMOR) on rat kidney lactate dehdrogenase and alkaline phosphatase activities have been investigated. The two enzymes were activated bby NMOR. This activations were maximum at 12th hour for alkaline phosphatase and at 24th hour for lactate dehydrogenase.NMOR was injected in dose of 160 mg per kg of body weight intraperitonally. At the 6th, 12th, 18th, 24th, 30th hours of injection, kidneys were taken out and homogenised in fold phosphate buffer. The homogenate was centrifuged at 10 000 g for 20 minutes and supernatant was used as a suource of enzyme. As for controls physiological serum was injected likewise.
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