Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2023 , Vol 27 , Issue 6
Synthesis, characterization and biological evaluation of some novel sulfonylurea derivatives
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Istanbul 34854, Turkiye
2Department of Chemistry, Faculty of Sciences, Muğla Sıtkı Koçman University, Muğla 48000, Turkiye
3Department of Medicinal and Aromatic Plants, Köyceğiz Vocational School, Muğla Sıtkı Koçman University, Muğla 48800, Turkiye
DOI : 10.29228/jrp.529 In this study, some new sulfonylurea derivatives based on the sulfanilamide compound were synthesized. IR, 1H-NMR, 13C-NMR spectroscopic methods and elemental analysis data were used to confirm the structures of the synthesized compounds. ABTS, DPPH, Cuprac and β-Carotene/linoleic acid assays were performed to evaluate the antioxidant activities of sulphonylurea derivatives. The activities of these compounds against some enzymes (acetylcholinesterase, butrylcholinesterase, tyrosinase, α-amylase and α-glucosidase) were also investigated. Compounds S7, S8, S13 and S14 showed inhibitory activity against α-amylase enzyme with IC50 values of 227.84±1.48- 298.27±8.61 μM. In addition, the drug-likeness properties and solubility of the compounds were determined by computational programs. Keywords : Sulfonylurea; antioxidant; cholinesterase; tyrosinase; α-amylase; α-glucosidase
Marmara University