¹Department of Pharmacology, Faculty of Pharmacy, Marmara University, Maltepe 34854 Istanbul, Türkiye
²Department of Pharmacology, Institute of Health Sciences, Marmara University, Kartal 34865 Istanbul, Türkiye
³Department of Toxicology, Faculty of Pharmacy, University of Health Science, Uskudar 34668 İstanbul, Türkiye
⁴Department of Pharmacognosy, Faculty of Pharmacy, Marmara University, Maltepe 34854 Istanbul, Türkiye DOI : 10.29228/jrp.523 Alzheimer's Disease (AD), which is quite prevalent in our society, not only makes the lives of patients and their families more challenging but also brings significant economic burdens. Sideritis species are widely used in folk medicine due to their various effects such as anti-inflammatory, antimicrobial, diuretic, and antispasmodic properties. Although there are many studies with the hypothesis that ROS is effective in the pathogenesis of neurodegenerative diseases, there are not enough studies on Sideritis germanicopolitana Bornm. subsp. viridis Hausskn. ex Bornm. (SGV) and Sideritis libanotica Labill. subsp. linearis (Bentham) Bornm. (SLL) species. In this study, the antioxidant activities of SGV and SLL plant extracts were compared using DPPH, FRAP, and CUPRAC methods to aid in AD treatment research. It was determined that SGV extract has higher DPPH (0.023±0.005 mg/mL), FRAP (1.074± 0.180 mM FeSO4/mg extract) and CUPRAC (2,988± 0,041 mM trolox equivalent/mg extract) activity potential than SLL extract. Additionally, as a result of cytotoxicity studies performed on SH-SY5Y neuroblastoma cells, ethanol extracts of SGV may be more suitable for use in AD at higher concentrations (250 μg/mL). Keywords : Sideritis germanicopolitana viridis; Sideritis libanotica linearis; Alzheimer; antioxidant activity; anticholinesterase activity