Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal
1993 , Vol 9 , Issue 1
The investigation about the binding responcible site of the subclasses type II IgG-IgG1 which bind non specific estradiol receptor
IgG1 subclass of type II IgG which binded estradiol receptor was seperated its fragments. The binding site of Ig 6 molecul to estradiol receptor has been investigated. First IgG1 was incubated with pepsin with papain. The fragments of IgG were seperated by Sephadex and ion exchange affinity chromotogragphies. The separeted fragments were incubated with radiolabeled estradiol receptor. The formation of Ig 6 - estradiol receptor complex had been shojn by sucrote gradient centrifugation. This shows that Fc site of IgG binds to estradiol receptor.
Keywords :
Immunoglobulin, estradiol receptor, IgG subclasses