¹Department of Pharmaceutical Technology, Hamidiye Faculty of Pharmacy, University of Health Sciences, Istanbul, Türkiye
²SFA R&D Private Health Services, Teknopark Blv, No:1 3A Z01, Teknopark Istanbul, Pendik, Istanbul, Türkiye
³ATABIO Technology, Department of Microbiology, Ahmet Yesevi mh, Kerem Sk, Teknopol Istanbul, Pendik, İstanbul, Türkiye DOI : 10.29228/jrp.488 Antiperspirants are used many times a day to prevent bad odor in the armpit. Bad odor under the armpit is called organic volatile molecules. It is formed by the metabolism or breakdown of sweat secreted from sweat glands by microorganisms in the axillary region. Antiperspirants prevent sweat secretion by blocking the sweat glands thanks to the active ingredients in the antiperspirants and prevent the formation of bad odor by stopping the bacteria from metabolizing the secretions. These active substances are still used today as aluminum and its salts. Although the damage of aluminum salts on the skin is not fully known, their accumulation in the body causes toxicity. The search for new active substances to eliminate the negative health effects of the active substances used is still continuing today. The purpose of this research is to produce formulations containing active cosmetic ingredients with natural components that can be used in new formulations. Moreover, it includes the evaluation of the efficacy of active substances that will provide inhibition of bacteria that cause bad odor in the axillary microbiota by adding them to formulations. In studies conducted by adding Lactobacillius lysates (Acilac ATA-LTW12- Lactobacillus ferment lysate extract) obtained from probiotics combined with Humulus lupulus extract, Salvia officinalis leaf extract to the formulation, a decrease in microorganisms causing bad odor formation was observed. Microbiota differences between the formulation with and without postbiotics applied in an artificial axillary microbiota environment were observed. It was observed that the Lactobacıllus ferment lysate extract component used in the reduction of bad odor-causing microorganisms supported specific inhibition in the natural armpit microbiota and normalized the microbiota. There was no statistically significant difference between the negative control (PBS) and the antiperspirant without postbiotics. Significant statistical differences were observed between the antiperspirant containing postbiotic (Acilac ATA-LTW12- Lactobacillus ferment lysate extract) and the antiperspirant without postbiotic, and between the antiperspirant containing postbiotic and negative control. As a result, a new one has been added to the roll-on type antiperspirant formulation studies with natural ingredients free of aluminum salts, sustainable to nature, and presented to the literature for development. Keywords : Cosmetic; formulation; postbiotic; antiperspirant; axillary microbiota