Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2023 , Vol 27 , Issue 5
Human Biomonitoring of Trace Elements (Zn, Cu, Mn, Cd and As) Level in a Healthy Urban Population in Türkiye
Esma SOYLEMEZ1,Eren OZCAGLI3,Eylem Funda GOKTAS4,Fulya KUREKCI5,Gulden Zehra OMURTAG1
1Department of Pharmaceutical Toxicology, School of Pharmacy, Istanbul Medipol University, Istanbul, Türkiye
2Department of Pharmacology, Veterinary Drug Residue Laboratory, Pendik Veterinary Control Institute, Istanbul, Türkiye
3Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Türkiye
4Department of Pharmacology, Doping Control Laboratory, Pendik Veterinary Control Institute, Istanbul, Türkiye
5Department of Pediatric Neurology, Faculty of Medical, Istanbul University, Istanbul, Türkiye
DOI : 10.29228/jrp.487 Human biomonitoring (HBM) studies are carried out to examine the effects of environmental pollutants on human health and to identify risks to public health, with the increasing awareness of environmental pollution around the world. The aim of our study is to determine the level of trace elements and to perform preliminary human biomonitoring of a healthy urban population in Türkiye. For this purpose, healthy individuals living in the same region and not known to have occupational or any other exposures were included in the study. Element levels from serum/blood of volunteers were determined. In this study, Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used to analyze in order to determine the multi elements in a more precise way with an improved analytical quality of results. According to our study’s results, Mn and As (p<0.05) were found statistically significant with age. Smoking had an effect on Cd levels (p<0.01) and there were significant differences between males and females for only Zn (p<0.05). The results of our study provided more information on the reference values of Zn, Cu, Mn, Cd and As elements of the Turkish population and reported the influences of age, gender and smoking habits on trace element profiles. Keywords : Biomonitoring; trace elements; ICP-MS; blood; serum
Marmara University