¹Department of Pharmaceutics, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta, Indonesia
²Department of Pharmacy, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta, Indonesia DOI : 10.29228/jrp.469 Film-forming polymers and plasticizers are components of orally dissolving film (ODF) compositions that have the greatest influence on the physical properties of the film preparations. Modification of sorghum starch produces maltodextrin (MDX)-sorghum which can be used as a film-forming polymer, and glycerol can be used as a plasticizer in ODF preparations. This study aims to determine the optimal concentrations of MDX-sorghum and glycerol to produce ODF compositions using the central composite design (CCD) in response surface methodology (RSM). Hydrolysis of sorghum starch yielded MDX-sorghum, characterized by yield value, dextrose equivalent (DE) value, solubility, swelling power and FTIR analysis. The CCD included a concentration range of 2-6% and 3-10% for MDXsorghum and glycerol, respectively, as parameters in the optimization process, so 14 experimental designs were obtained. The test response was evaluated using tensile strength, elongation and disintegration time tests. The modification of sorghum starch yields a light brown MDX-sorghum powder with desirable properties. Optimization of MDX-sorghum and glycerol concentrations yielded an optimal formulation with a tensile value of 1.50 mPa with an error percentage of 0.33%, elongation of 104.26% with an error percentage of 0.25%, and disintegration time of 82.95 seconds with an error percentage of 0.06%. By modifying sorghum starch into MDX-sorghum, the starch's ability to dissolve and swell can be improved, allowing it to be used as a film-forming polymer. The optimal MDX-Sorghum and glycerol concentrations for the production of ODF are 3.56% and 10.00 %, respectively. Keywords : Sorghum strach, modified, film-forming, glycerol, response surface methodology