Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2023 , Vol 27 , Issue 1
Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats
Dicle KARGIN1,Şule AKTAÇ2,Ayse Nur HAZAR YAVUZ3,Muhammet Emin ÇAM3
1Department of Nutrition and Dietetics, Institute of Health Sciences, Marmara University, İstanbul 34854, Turkey
2Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, İstanbul 34854, Turkey
3Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34716, Turkey
DOI : 10.29228/jrp.325 Cornelian cherry (Cornus mas L.) has been used for centuries as a traditional herbal medicine in Europe and Asia. In this study, we aimed to describe the effect of Cornus mas L. (C. mas) on the activity of the antioxidant enzymes and a detoxification agent in rats fed a high-fat diet. Forty-eight adult sprague dawley rats were randomly assigned to six groups of eight animals each: Standard diet (Control), High Fat Diet (HFD), HFD + C. mas (200 mg/kg/day; 8 weeks), HFD + Atorvastatin (20 mg/kg/day; 8 weeks), HFD post treated with C. mas (200 mg/kg/day; 4 weeks), HFD post treated with Atorvastatin (20 mg/kg/day; 4 weeks). The activity of the antioxidant enzymes, Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), detoxification agent glutathione (GSH) and oxidative stress parameter thiobarbituric acid reactive substances (TBARS) were measured in the liver tissues. GPx, SOD, and CAT enzyme levels were decreased in HFD groups compared to the control (p < 0.05). However, Cornus mas L. promoted antioxidant activity by increasing GPx, SOD, and CAT enzymes and It also reduced oxidative stress (as an increase in GSH) both in the HFD + C. mas group and the HFD post-treated C. mas group compared to the HFD group (p < 0.05). Our study showed that feeding a high-fat diet increases oxidative stress. Cornus mas L treatment improves antioxidant enzyme activity and oxidative stress parameters in the liver tissues of rats. Keywords : Cornus mas L.; liver; antioxidant; glutathione; high-fat-diet
Marmara University