¹Department of Biology, Faculty of Arts and Science, Bitlis Eren University, Bitlis, Turkey
²Department of Biology, Faculty of Science, Fırat University, Elazığ, Turkey DOI : 10.29228/jrp.314 The objectives of this work were to evaluate the antimicrobial activities, antioxidant in vitro cytotoxicity and DNA damage of Pleurotus ostreatus (Jacq.) P. Kumm. cultivation on some local cellulosic substrates. It observed to be very active against bacteria (except S. mutans and K. pneumonia), yeast and dermatophytes when compared to the control groups (10.0-32.7 mm). It also showed significant antioxidant potential, the highest TAS (0.978 mmol/L) and TOS (10.51 μmol/L) values were obtained in M-P (1:1) and W, and also DPPH radical scavenging effects was more effective at 25 mg (74.80%) on MS. The methanol extract of P. ostreatus cultured on M-W (2.35%) and M-P (1:1) (9.74%) at 400 μg/mL concentration has remarkably decreased the percentage of viability in MDA-MB-231 and A-549 cell lines. However, it has been determined that P. ostreatus does not have a DNA protective effect. These results indicate that P. ostreatus has potent antimicrobial, antioxidant, as well as cytotoxic effects. Keywords : P. ostreatus; edible mushroom; medicinal effect; cytotoxicity; DNA damage