¹Glocal School of Pharmacy, Delhi-Yamunotri Marg (State Highway 57), Mirzapur Pole, Dist - Saharanpur, U.P. - 247121, India
²School of Pharmaceutical Sciences, Apeejay stya University, Sohna-Palwal Road, Sohna, Gurugram, Haryana, 122103 DOI : 10.29228/jrp.273 In this paper we examined the Withania somnifera extract (WSE) improve cognitive, behavioral and mood disorder in animal model of bipolar disorder. The present study was undertaken to investigate cognitive, behavioral and mood disorder effects of WSE on bipolar disorder of the male/female Wistar albino rats’ brain. We have observed after 24 hours of last dosing the behavioral, memory and test were carried out followed by estimation of markers of oxidative stress under six groups using continuous sub-anesthetic dose of Amphetamine (Amph) (1.5 mg/kg, i.p) with WSE (300 mg/kg, i.p) and LiCl (1.5 mEq/kg, i.p.) administered daily for 21 days. We have found the percentage alteration was decreased in rat treated with WSE as compared to control indicate that it also improved spatial memory and learning. We have examined various oxidative parameters such as levels of SOD, GSH and TBARS level as compared to control groups. The reduced level of oxidative stress parameters upon administration of WSE and LiCl indicates ameliorating effects of WSE in oxidative stress. We had concluded that WSE showed improvement in learning and memory as animal treated with WSE spent more time in open arm as compared to Amph with WSE and LiCl treated rats. Hence, we can say that WSE improve cognitive, behavioral and mood disorder in animal model of bipolar disorder. Keywords : Withania somnifera extract; cognitive; behavioral; mood disorder; animal model; bipolar disorder