¹Department of Pharmacy, Faculty of Sims College of Pharmacy, Guntur, India-522001 DOI : 10.29228/jrp.272 Neurodegenerative diseases are increasing worldwide, and new drugs to treat them effectively with fewer side effects are in high demand today. Treatments available for these diseases are associated with significant side effects in the long term. Therefore, finding a therapy that inhibits disease progression with fewer side effects is crucial. Origanum majorana commonly called sweet marjoram was reported to have a wide range of health benefits particularly in treating neurological diseases. In this context, the leaf extract of Origanum majorana was evaluated for its antioxidant, antiparkinson’s and neuroprotective properties. The antioxidant property was assessed by two in-vitro methods, nitric oxide radical scavenging assay and phosphomolybdenum assay. The antiparkinson’s property was assessed in haloperidol-induced Parkinson's disease in mice using the catalepsy bar test and rotarod test. The results of this study show that Origanum Majorana has a powerful antioxidant property that can protect neurons from haloperidol-induced cognitive and motor impairments by reducing oxidation. Keywords : Neurodegenerative diseases; Origanum majorana; Parkinson's disease; antioxidant and neuroprotective properties