¹Department of Medical Laboratory, Vocational School of Health Services, Mardin Artuklu University, Mardin 47200 Turkey
²Department of Chemistry, Faculty of Science, Dicle University, Diyarbakir 21280 Turkey
³Department of Chemistry, Faculty of Science, Mugla Sıtkı Kocman University, Mugla 48121 Turkey
⁴Department of Biology, Faculty of Education, Van Yüzüncü Yıl University, Van 65080 Turkey
⁵Department of Pharmacognosy, Faculty of Pharmacy, Dicle University, Diyarbakır 21280 Turkey
⁶Department of Analytical Chemistry, Faculty of Pharmacy, Dicle University, Diyarbakir 21280 Turkey DOI : 10.29228/jrp.220 The importance of plants in folk medicine and scientific studies is increasing day by day. In this context, the plants pose a danger to human health when they are eaten by the public, consumed as herbal tea or used as medicinal plants especially the toxic metals in their composition. For this reason, determining the macro, micro and toxic element content in the plants is important for health. In this study; the metal contents of root and aerial parts of nine different Salvia species were determined and the chemometric evaluation of the obtained results was made. In the principal component analysis (PCA) made with 20 elements of Salvia species, it was determined that the first two principal components explained 62.60% of the variance and the first six principal components explained 92.70%. When PCA and hierarchical cluster analysis (HCA) results are evaluated; the parts of Salvia species root and aerial parts were determined that were not clearly separated and there was no regional grouping. In addition, Salvia species prepared as herbal tea was left to different simulated body fluid medium conditions, and the changes in metal contents were examined. It was determined that were taken up Cr, Cd, Pb, Cu, Zn metals in the simulated saliva fluid (SSF), Ni, Mn metals in the simulated gastric fluid (SGF), and Na, K metals in the simulated intestinal fluid (SIF). It was determined that Fe metal in almost all Salvia species was not taken from three simulated body fluid mediums. Thus, elements determined which were taken up in body fluid mediums. Keywords : Salvia; chemometry; SSF; SGF; SIF; FAAS