Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2022 , Vol 26 , Issue 5
Antiestrogenic and toxicological evaluation of methanolic extract of Saraca asoca and Cynometra travancorica
Suhail PT1,Sheron Joseph2,Ajeesh V3,Sreelakshmi SS4,Krishnapriya Anil5
1Department of Pharmacology, Al Shifa College of Pharmacy, Perinthalmanna, Kerala
2Department of Pharmaceutics, Al Shifa College of Pharmacy, Perinthalmanna, Kerala
3Department of Pharmaceutical Chemistry, Al Shifa College of Pharmacy, Perinthalmanna, Kerala
4Department of Pharmacology, Al Shifa College of Pharmacy, Perinthalmanna, Kerala
5Department of Pharmacology, Al Shifa College of Pharmacy, Perinthalmanna, Kerala
DOI : 10.29228/jrp.218 Saraca asoca, a member of the Caesalpinaceae sub-family, is a native plant utilized extensively in ayurvedic medicine. Excessive menstrual bleeding, bleeding hemorrhoids, bleeding ulcers, and hemorrhagic dysentery can all be treated with the tannins found in the bark of S. asoca. Due to the scarcity of S. asoca, the ayurvedic formulation business was forced to use barks of comparable origin. Until recently, the pharmacological potential of frequently substituted Cynometra travancorica was unknown. The purpose of this research is to investigate and evaluate the antiestrogenic and toxicological effects of two Caesalpiniaceae members, S. asoca and C. travancorica, on Wistar female rats. Methanolic bark extract of both plants (600 mg/kg) was shown to be significantly effective in reducing the elevated estrogen (20 μg/animal) levels in Wistar female rats. The C. travancorica treated group showed an 85.63 ± 11.38 pg/ml reduction. In the toxicological evaluation, even at high concentrations of 800 mg/kg, neither of the extracts was fatal to Swiss albino mice. Food and water consumption, body weight, and the weight of organs such as the liver, kidney, spleen, heart, and lungs did not change significantly. The hematological parameters also stagnated. The study concluded that C. travancorica had shown a substantial and comparable anti-estrogenic effect to S. asoca in Wistar female rats and, similarly, the toxicological evaluation of the former plant was analogous to the latter. As a result, C. travancorica has a comparable therapeutic and safety profile in a wide range of ayurvedic formulations. Keywords : Saraca asoca; Cynometra travancorica; Caesalpinaceae; anti-estrogenic activity; toxicological evaluation
Marmara University