Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 1991 , Vol 7 , Issue 1
Spectrophotometric determination of baclofen in tablets with 1,2-naphtoquinone-4-sulphonic acid sodium salt
Zafer Bilgiç,Sedef Atmaca,Gülsen İskender
A spectrophotometric method was developed for the determination of baclofen alone and in tablets. The method was based on condensation reaction baclofen with 1,2-naphthoquinone-4 acid sodium salt (NQS), at pH 7.5 and 70°C within 20 min., when the molar ratio NQS to baclofen was 4. After the extraction of the derivative with dichloromethane : n-butanol (4:1), absorbance was measured at 455 nm. A linear relationship between absorbance and concentration was obtained over the range of 5-50 g. ml -1 of baclofen. The results of the analysis of baclofen tablets so obtained correlated well with those obtained by the offical method at 95% confidence level. Keywords :
Marmara University