Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2022 , Vol 26 , Issue 4
Synthesis and antioxidant activity of benzo[a]pyrano[2,3- c] phenazine derivative compound via one-pot multicomponent reaction
Agus Rimus Liandi1,Antonius Herry Cahyana2
1Department of Chemistry, Faculty of Science and Technology, Syarif Hidayatullah State Islamic University Jakarta, Tangerang Selatan, 15412, Indonesia
2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia
DOI : 10.29228/jrp.193 Phenazine derivative compounds are of concern because of their extraordinary activities in medicine. The aim of this study is to synthesize the derivative of benzo[a]pyrano[2,3-c] phenazine compound based on lawsone with caffeine catalyst using the one-pot multicomponent reaction method and test its antioxidant activity. The formation of the target compound was evaluated for functional group vibration, maximum wavelength, and molecular weight by FTIR, UV-Vis Spectrophotometer, and LCMS, which showed the characteristics of the benzo[a]pyrano[2,3-c] phenazine compound. The synthesized compound was 3-amino-2-cyano-1-(2-hydroxyl-phenyl)-1H-benzo[a]pyrano[2,3-c] phenazine with the molecular formula C26H16N4O2. At the optimum condition of the reaction, the use of caffeine catalyst was able to give a product yield of 67.2%. The potential of the synthesized compound as an antioxidant could be classified as a good antioxidant with an IC50 value of 14.26 ppm. Keywords : Benzo[a]pyrano[2,3-c] phenazine; lawsone; one-pot multicomponent reaction; antioxidant; caffeine catalyst
Marmara University