¹Department of Chemistry, Faculty of Science and Letters, Tekirdag Namik Kemal University, Tekirdag, Turkey DOI : 10.29228/jrp.141 Biosensing can be used for analysis, diagnosis and determination of biological target structures. But the improvement of sensitivity and sensing threshold is an important problem to overcome. It is possible to solve this problem with metal nanoparticles, in some linear response range while decreasing the threshold value. The synthesis of nanostructured materials, especially metallic nanoparticles, has accrued utmost interest over the past decade owing to their unique properties that make them applicable in different fields of science and technology. The article is divided into subsections on sensors based on nanoparticles made from Au, Cu and other metals for miRNA detection. Keywords : miRNA; biosensor; metal nanoparticles; detection