Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2022 , Vol 26 , Issue 1
A new perspective for biological activities of novel hexahydroquinoline derivatives
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100, Sihhiye-Ankara, Turkey
2Department of Chemistry, Polatlı Faculty of Arts and Sciences, Ankara Hacı Bayram Veli University, 06900, Polatlı-Ankara, Turkey
3Ankara University, Biotechnology Institute, 06135, Keçiören-Ankara, Turkey
DOI : 10.29228/jrp.120 Cancer is a systemic disease that occurs by various molecular mechanisms and its certain treatment has not been achieved yet. Antimicrobial drugs are the only option for the treatment of infections cause by bacteria and fungi. However, most microorganisms might develop resistantance against these drugs. 1,4-Dihydropyridine (1,4-DHP) is a partially saturated form of pyridine ring which shows calcium channel modulator activity. In addition to this activity of 1,4-DHPs and analog compounds such as hexahydroquinoline (HHQ), other activities have also been investigated. In this study, two new HHQ derivatives were synthesized to obtain a lead compound which has anticancer and antimicrobial activity. The structures of the synthesized compounds were proved by spectral methods. These HHQ derivatives compounds were conjugated to magnetic nanoparticles to investigate the changes in their anticancer and antimicrobial activities. For this purpose, firstly, we synthesized silica-coated magnetic nanoparticles. The silica-coated magnetic nanoparticles were conjugated with HHQ to enhance anticancer and antimicrobial activities. Anticancer and antimicrobial activity studies were carried out for both compounds and magnetic nanoparticle (MNP) forms. In addition, the physicochemical and pharmacokinetic properties, lipophilicity, water solubility and druglikeness of the compounds were determined in silico. Altogether, our data indicate that the new hexahydroquinoline derivatives have anticancer activity and the magnetic nanoparticle form led to increasing to this activity. Keywords : Hexahydroquinoline; magnetic nanoparticle (MNP); anticancer; antibacterial; antifungal; synthesis; spectra; Hantzsch reaction
Marmara University